Cambridge Healthtech Institute’s 7th Annual

Difficult to Express Proteins
3-4 November 2014


This opening meeting of the protein stream for PEGS Europe will focus on the “finicky” proteins that are extremely challenging to expression. Vaccines, hormones, membrane proteins, ion channels, low-abundance proteins and protein complexes continue to cause issues for bench scientists.  This meeting will focus on the novel and imaginative solutions for these problems.


Topics will include, but are not limited to the following: 

Persistent Problems 

  • Controlling glycosylation, folding, immunogenicity, stability, etc.
  • Expressing toxic proteins
  • Managing disulfide bonds
  • Inclusion bodies
  • Low yields
  • Non-active expression results


Novel Solutions 

  • Transient transfection
  • Cell-free expression
  • Protein complexes
  • New ways to utilize old hosts
  • Novel vectors and gene constructs 


Case Studies in Success and Failure 

  • Novel solutions for finicky proteins
  • Failure as a key to future success
  • How changing the host solved the problem


If you would like to submit a proposal to give a presentation at this meeting, please click here.


Deadline for submission is 21 March 2014 


All proposals are subject to review by the Scientific Advisory Committee to ensure the highest quality of the conference program. Please note that due to limited speaking slots, preference is given to pharmaceutical and biotech companies, regulators and those from academia. Additionally, vendors/consultants who provide products and services to these biopharmaceutical companies are offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships. 


For more details on the conference, please contact:  

Elizabeth J. Lamb
Senior Conference Director
Cambridge Healthtech Institute
Tel: 781-247-6259


If you are interested in exhibiting or sponsoring, please contact: 

Carol Dinerstein
Director, Business Development
Cambridge Healthtech Institute
Tel: 1 781-972-5471