Conference Short Courses*

Short Courses Maximize Your Productivity

Maximize your educational and networking opportunities while in Lisbon by adding a short course. Continued training and education are essential for staying competitive. These interactive short courses are a great introduction for those new to a particular discipline or as a refresher for those who want to brush up on their knowledge or expand their horizons. Attendance is limited to ensure an interactive environment. Group discussions are a key component in which participants will have the opportunity to ask questions of the expert instructors and other participants. Course materials are included.

Monday, 3 November 09:00 – 12:30

SC1: Engineering of Bispecific Antibodies - (Detailed Agenda) 

Instructors: Nicolas Fischer, Ph.D., Head, Research, Novimmune SA

Julian Bertschinger, Ph.D., CEO, Covagen

By attending this interactive workshop, you will learn about the various approaches used for the engineering of bispecific antibodies and bispecific scaffold-based binding proteins. Different technologies will be compared, and examples for applications of bispecific antibodies in drug development will be presented with a focus on candidates that are currently being evaluated in clinical trials. Opportunities and challenges in the field of bispecific antibodies will be discussed.

SC2: Mutation and Selection Strategies for Multi-Parameter Antibody Optimisation - (Detailed Agenda) 

Instructors: William Finlay, Ph.D., Director, Global Biotherapeutic Technologies, Pfizer, Inc.

Matthew Lambert, Ph.D., Principal Scientist, Global Biotherapeutic Technologies, Pfizer, Inc.

In therapeutic antibody discovery, few primary lead antibodies meet all of the desired product characteristics of ideal potency, expression, stability, formulation and immunogenicity. As a result, in vitro engineering is often necessary ranging from basic humanization all the way up to affinity, stability and solubility improvement. In recent times, a bewildering array of potentially useful mutagenesis, selection and screening technologies have become readily available to perform these tasks. In this course we will help attendees to critically assess their options and navigate through this complex field.

Thursday, 6 November 17:30 – 20:30 To include Dinner

SC5: Aggregation and Immunogenicity: How Do Formulation, Process and Delivery Influence Immunogenicity of Therapeutic Proteins? - (Detailed Agenda) 

Instructors: Melody Sauerborn, Ph.D., Head of Non-Clinical Development, Mymetics BV and CEO, ADA InVivo

Joel Richard, Ph.D., Senior Vice President, Peptides, Head, CMC & Engineering Dreux Site, IPSEN

Formation of anti-drug antibodies (ADA) represents a risk for the patient as it possibly alters pharmaco-kinetics and compromises safety and efficacy. The course will review the immunogenicity aspects related to formulation composition, excipients, storage and in-process stability issues. The focus will be on the influence of degradation products (oxidized forms, aggregates, particulates, etc.) and process-related impurities (contaminants, particulates) on the immune system. In addition, key analytical methods for identification, characterisation and composition determination of aggregates/particulates in the formulation will be reviewed, particularly the characterisation of aggregates/particulates in the lower sub-visible size range. We will also discuss how in-depth formulation analysis can be connected to biological consequences of aggregates and particulates.

SC6: Troubleshooting and Engineering of Antibody Constructs - (Detailed Agenda) 

Instructors: Jonas V. Schaefer, Ph.D., Head, High-Throughput Laboratory, Biochemistry, University of Zurich

Christian Kunz, Ph.D., Associate Director, Discovery Alliances & Technologies, MorphoSys AG

Recombinant antibodies vary widely in their biophysical characteristics, from stable monomers to metastable aggregation-prone oligomers. In particular, antibody variable domains differ in their intrinsic thermodynamic stability and often require labor-intensive engineering. While most antibody engineering is performed with small antibody fragments, the majority of molecules in the clinics still are of the full-length IgG format. Thus it is critical to understand how the poor stability of individual variable domains not only limits the biophysical properties of small fragments, but also affects the production yield, stability and homogeneity of full-length IgGs containing these domains.

SC7: Immunotherapy Approaches - (Detailed Agenda) 

Instructors: Andrea van Elsas, CSO, BioNovion B.V.

Sergio A. Quezada, Ph.D., Professorial Research Fellow, Research Haematology, University College London Cancer Institute

Cancer immunotherapy is distinct from other paradigms in that treatment is directed towards a patient’s immune system and not their malignant cells. During the past few years, novel approaches to immunotherapy of cancer using antibodies targeting T cell regulatory proteins produced highly encouraging clinical data. Patients responding to T cell check-point inhibitors have shown long-term benefit suggesting that, in addition to surgery, radiotherapy and (targeted) chemotherapy, immunotherapy will become a novel treatment paradigm in oncology. Besides targeting T cell checkpoint proteins other pathways and novel agents are being investigated to induce or enhance anti-tumour immunity.

*separate registration required for short courses