As pharma increasingly shifts its attention to biologics, more attention is being paid to developing biotherapeutics against membrane-bound targets - and the rapid adoption of ML and other advanced computational tools offers an exciting and expanded toolkit for R&D scientists working in this space. For 2024, the 3rd Annual PEGS Europe Antibodies Against Membrane Protein Targets conference explores various antigen strategies, emerging modalities and promising avenues for expanding the druggable space via computational tools, novel target identification methods, and advanced understandings of protein signaling. The latest advancements in antibody discovery will be covered, including in silico approaches, transgenic models, and synthetic libraries.