The balance between optimizing a molecule’s therapeutic properties and ensuring its successful development lies at the heart of every biotherapeutic design. The 15th Annual Optimisation & Developability conference will delve into the strategies and cutting-edge tools used to navigate this challenge. Attendees will explore how to assess developability risks, tailor molecular properties for binding, specificity, half-life extension, stability, and formulation assessment for a variety of formats, using a toolbox of physics-based, in silico and machine learning approaches.