The T Cell Engagers conference brings together leaders advancing safer, more selective strategies for solid tumor targeting. Sessions will highlight conditionally activated and masked TCE platforms designed to restrict activity to the tumor microenvironment, aiming to widen the therapeutic window while protecting healthy tissues. Experts will also showcase next-generation engineering concepts, including co-stimulatory designs, logic-gated constructs, and effector-biased molecules that fine-tune T cell activation and function. Finally, the agenda explores combination and dual-modality approaches to turn cold tumors hot and maximize the clinical impact of bispecific T cell therapies in solid tumors.