Tailoring a molecule’s properties to improve its binding, specificity, half-life, or therapeutic index will greatly improve its chance of success in the clinic. Similarly, assessing and predicting a molecule’s developability will improve its candidacy for advancement into the clinic. The 14th Annual Optimisation & Developability conference will present strategies to optimise drug properties, design molecules with the right developability properties, assess and predict stability and manufacturability, etc., using a toolbox of molecular dynamics, simulation, in silico prediction, and AI approaches.