Cambridge Healthtech Institute’s Inaugural

Innovations in CAR T Therapy and Engineering in vivo Solutions

Improving Access and Overcoming Challenges

15 November 2023

CAR T therapy holds unprecedented promise for not just the treatment but the curing of cancer; however, barriers include complex procedures, high cost of implementation and manufacturing, and the application to solid tumors. Accordingly, many developments are ongoing to improve CAR activities as well as their generation. In vivo gene delivery to T cells holds promise as a therapeutic platform to treat various diseases by a simpler and less expensive means. The generation of chimeric antigen receptor (CAR) T cells in vivo can be achieved by delivering mRNA in T cell-targeted lipid nanoparticles (LNPs) and in vivo programming. This novel track at PEGS Europe will review innovative CAR structures, gene-editing tools, and gene delivery techniques applied in immunotherapy to help design and develop new CAR constructs and engineer in vivo therapies. Various approaches and technologies will be assessed for their immunogenicity, potency, and modes of CAR delivery, both permanent and transient. This conference will examine what it will take to transform new CAR constructs and in vivo CAR therapy from proof-of-concept to a robust technology for clinical use.  

Coverage will include, but is not limited to:

  • Overcoming the tumor microenvironment
  • Enabling T cell therapy for solid tumors
  • Creating and optimizing novel CAR constructs
  • Employing gene editing and in vivo programming
  • Improving manufacturing, scale-up processes, and access to therapy
  • Advancing delivery using lipid nanoparticles and mRNA

The deadline for priority consideration is 31 March 2023.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation:

For more details on the conference, please contact:

Christina Lingham
Executive Director, Conferences and Fellow
Cambridge Healthtech Institute
Phone: (+1) 781-972-5464

For sponsorship information, please contact:

Companies A-K
Jason Gerardi
Sr. Manager, Business Development
Cambridge Healthtech Institute
Phone: (+1) 781-972-5452

Companies L-Z
Ashley Parsons
Manager, Business Development
Cambridge Healthtech Institute
Phone: (+1) 781-972-1340