Cambridge Healthtech Institute’s 14th Annual

Optimisation & Developability

Improving Candidate Selection and Lead Optimisation

14 November 2023

Tailoring a molecule’s properties to improve its binding, specificity, half-life, or therapeutic index will greatly improve its chance of success in the clinic. Similarly, assessing and predicting a molecule’s developability will improve its candidacy for advancement into the clinic. The 14th Annual Optimisation & Developability conference will present strategies to optimise drug properties, design molecules with the right developability properties, assess and predict stability and manufacturability, etc., using a toolbox of molecular dynamics, simulation, in silico prediction, and AI approaches.

Coverage will include, but is not limited to:

  • Optimising drug properties
    • Optimise molecules to have certain developability parameters
    • Multi-parameter optimisation
    • Predicting stability
    • Engineering mutations to increase stability
    • Predicting immunogenicity and formulation strategies
    • Developability assessment
    • Developability-by-design – designing molecules to have the right developability and TCP properties
    • Assessing expressibility, chemical and thermal stability, viscosity, polyspecificity, manufacturability, PK, Solubility, etc.
  • Molecular dynamics simulation and physics-based modeling for developability assessment
    • How do you model developability?
    • Training models to connect developability to sequencing
  • Computation and AI approaches to developability evaluation and structure-function prediction
    • in silico tool to design better sequences
    • optimising sequence on developability properties
    • sampling challenges

The deadline for priority consideration is 31 March 2023.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation:

For more details on the conference, please contact:

Mimi Langley
Senior Conference Director
Cambridge Healthtech Institute
Phone: (+1) 781-972-5439

For sponsorship information, please contact:

Companies A-K
Jason Gerardi
Sr. Manager, Business Development
Cambridge Healthtech Institute
Phone: (+1) 781-972-5452

Companies L-Z
Ashley Parsons
Manager, Business Development
Cambridge Healthtech Institute
Phone: (+1) 781-972-1340