Cambridge Healthtech Institute’s 14th Annual
Optimisation & Developability
Improving Candidate Selection and Lead Optimisation
14 November 2023
Tailoring a molecule’s properties to improve its binding, specificity, half-life, or therapeutic index will greatly improve its chance of success in the clinic. Similarly, assessing and predicting a molecule’s developability will improve its candidacy for advancement into the clinic. The 14th Annual Optimisation & Developability conference will present strategies to optimise drug properties, design molecules with the right developability properties, assess and predict stability and manufacturability, etc., using a toolbox of molecular dynamics, simulation, in silico prediction, and AI approaches.
Coverage will include, but is not limited to:
- Optimising drug properties
- Optimise molecules to have certain developability parameters
- Multi-parameter optimisation
- Predicting stability
- Engineering mutations to increase stability
- Predicting immunogenicity and formulation strategies
- Developability assessment
- Developability-by-design – designing molecules to have the right developability and TCP properties
- Assessing expressibility, chemical and thermal stability, viscosity, polyspecificity, manufacturability, PK, Solubility, etc.
- Molecular dynamics simulation and physics-based modeling for developability assessment
- How do you model developability?
- Training models to connect developability to sequencing
- Computation and AI approaches to developability evaluation and structure-function prediction
- in silico tool to design better sequences
- optimising sequence on developability properties
- sampling challenges
The deadline for priority consideration is 31 March 2023.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation:
For more details on the conference, please contact:
Mimi Langley
Senior Conference Director
Cambridge Healthtech Institute
Phone: (+1) 781-972-5439
Email: mlangley@healthtech.com
For sponsorship information, please contact:
Companies A-K
Jason Gerardi
Sr. Manager, Business Development
Cambridge Healthtech Institute
Phone: (+1) 781-972-5452
Email: jgerardi@healthtech.com
Companies L-Z
Ashley Parsons
Manager, Business Development
Cambridge Healthtech Institute
Phone: (+1) 781-972-1340
Email: ashleyparsons@healthtech.com