Cambridge Healthtech Institute’s 14th Annual

Optimisation & Developability

Improving Candidate Selection and Lead Optimisation

14 November 2023

Tailoring a molecule’s properties to improve its binding, specificity, half-life, or therapeutic index will greatly improve its chance of success in the clinic. Similarly, assessing and predicting a molecule’s developability will improve its candidacy for advancement into the clinic. The 14^th Annual Optimisation & Developability conference will present strategies to optimise drug properties, design molecules with the right developability properties, assess and predict stability and manufacturability, etc., using a toolbox of molecular dynamics, simulation, in silico prediction, and AI approaches.

Coverage will include, but is not limited to:

Optimising drug properties
- Optimise molecules to have certain developability parameters
- Multi-parameter optimisation
- Predicting stability
- Engineering mutations to increase stability
- Predicting immunogenicity and formulation strategies
- Developability assessment
- Developability-by-design – designing molecules to have the right developability and TCP properties
- Assessing expressibility, chemical and thermal stability, viscosity, polyspecificity, manufacturability, PK, Solubility, etc.
Molecular dynamics simulation and physics-based modeling for developability assessment

How do you model developability?
Training models to connect developability to sequencing

Computation and AI approaches to developability evaluation and structure-function prediction

in silico tool to design better sequences
optimising sequence on developability properties
sampling challenges

The deadline for priority consideration is 31 March 2023.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation:

To submit a podium presentation, please click here.
To become a sponsor, click here.
To present a poster, click here.
To sign up to attend, click here

For more details on the conference, please contact:

Mimi Langley
Senior Conference Director
Cambridge Healthtech Institute
Phone: (+1) 781-972-5439
Email: mlangley@healthtech.com

For sponsorship information, please contact:

Companies A-K
Jason Gerardi
Sr. Manager, Business Development
Cambridge Healthtech Institute
Phone: (+1) 781-972-5452
Email: jgerardi@healthtech.com

Companies L-Z
Ashley Parsons
Manager, Business Development
Cambridge Healthtech Institute
Phone: (+1) 781-972-1340
Email: ashleyparsons@healthtech.com