Cambridge Healthtech Institute’s 15th Annual

Optimisation & Developability

Improving Candidate Selection Leading to Clinical Success

5 November 2024


The balance between optimising a molecule’s therapeutic properties and ensuring its successful development lies at the heart of every biotherapeutic design. The 15th Annual Optimisation & Developability conference will delve into the strategies and cutting-edge tools used to navigate this challenge. Attendees will explore how to assess developability risks; tailor molecular properties for binding, specificity, half-life extension, and stability, and evaluate best formulation strategies for a variety of formats. We invite speakers to share their case studies demonstrating different approaches including physics-based, in silico, and machine learning approaches.

Coverage will include, but is not limited to:

  • Developability Risk Assessment
    • Identifying potential liabilities (aggregation, viscosity, stability issues) early in development
    • Proactive mitigation strategies to address potential developability risks
    • How early assessment may impact development success
    • Developability challenges of bispecifics, multispecifics, fusion proteins, ADCs, AAVs, and engineered cell therapies

     

  • Candidate Selection and Optimisation
    • Enable rapid screening of molecules to identify candidates for further development
    • Designing libraries with developability considerations
    • Optimise binding affinity and analyse conformational changes to avoid unwanted immune responses
    • High-throughput screening for formulation and excipient selection
    • Balancing development speed while mitigating potential risks

     

  • Computational and in silico Methods
    • Using sequence-based predictors for developability risks (aggregation-prone regions, liability hotspots)
    • Integrating AI and machine learning in developability prediction
    • Structural modeling to predict protein structure and identify sites for modification to improve stability and manufacturability

The deadline for priority consideration is 29 March 2024.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation:

For more details on the conference, please contact:

Mimi Langley
Senior Conference Director
Cambridge Healthtech Institute
Phone: (+1) 781-972-5439
Email: mlangley@healthtech.com

For sponsorship information, please contact:

Companies A-K
Jason Gerardi
Sr. Manager, Business Development
Cambridge Healthtech Institute
Phone: (+1) 781-972-5452
Email: jgerardi@healthtech.com

Companies L-Z
Ashley Parsons
Manager, Business Development
Cambridge Healthtech Institute
Phone: (+1) 781-972-1340
Email: ashleyparsons@healthtech.com