Cambridge Healthtech Institute’s 7th Annual

Modulating the Tumour Microenvironment

Decoding the TME

5 November 2024

The dynamics within the tumour microenvironment profoundly influence cancer progression, metastasis, and response to therapy. At the Modulating the Tumour Microenvironment conference, we invite speakers to examine the intricacies of the tumour microenvironment and share their cutting-edge advancements that will further our understanding of this dynamic landscape. Topics include utilising spatial biology tools to map the TME’s architecture, dissect the metabolic and signaling pathways shaping the immune function, and harness different immune cell populations to develop promising therapeutic approaches targeting the TME. We will also address the critical challenges in developing robust TME models that accurately bridge preclinical discovery with successful clinical translation.

Coverage will include, but is not limited to:

  • Spatial Proteo-Genomics
    • Spatial profiling and imaging for real-time analysis of the tumour microenvironment
    • Identifying cell-cell interactions that drive therapeutic resistance
    • Unraveling complex crosstalk between tumor cells, immune cells, and stromal components
  • Deeper Understanding of the Tumour Microenvironment
    • What’s driving immune resistance or immune escape?
    • Understanding the metabolic pathways and the role of tumour microenvironment in metastasis and treatment outcomes
    • Defining patient-specific TME profiles to guide personalised therapies
    • Tertiary Lymphoid Structures (TLS) and their role in immune surveyance and therapeutic responses
    • Cancer cell plasticity
    • Targeting the microbiome
  • Targeting the Tumor Stroma
    • Understanding the complex interactions between tumor cells and various stromal components
    • Targeting Cancer-Associated Fibroblasts (CAFs)
    • Extracellular matrices and their role in the TME
    • Anti-angiogenesis therapy
  • Harnessing Different Immune Cell Types to Enhance Anti-Tumour Response
    • NK cells
    • B cells
    • Neutrophils
    • Macrophages and myeloid cells
    • Dendritic cells
    • Gamma delta T cells
  • Developing Models for the TME
    • Translating in vitro findings to in vivo and clinical relevance
    • How to build models to investigate the best outcomes?
    • How do you model the TME?
    • How do you translate the data to create clinical trials?

The deadline for priority consideration is 29 March 2024.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation:

For more details on the conference, please contact:

Mimi Langley
Senior Conference Director
Cambridge Healthtech Institute
Phone: (+1) 781-972-5439

For sponsorship information, please contact:

Companies A-K
Jason Gerardi
Sr. Manager, Business Development
Cambridge Healthtech Institute
Phone: (+1) 781-972-5452

Companies L-Z
Ashley Parsons
Manager, Business Development
Cambridge Healthtech Institute
Phone: (+1) 781-972-1340